By way of introduction, I decided to write this post because I do not understand the current violent attacks against Bryan Johnson, the Blueprint stack, or more generally the idea of "don't die". Trying not to die, or at least trying to avoid dying "right away", still seems to me to be one of the few subjects on which the whole of humanity ought to be able to agree.
Now it is true that my opinion is far from neutral, but let me tell you why:
Five years ago, I am dying, hospitalized for a month. Diagnosis: a severe form of Crohn's disease. Since then, I have been on biotherapy (Infliximab), a treatment that significantly improves my condition. Undeniably. But I remain weakened: each infusion knocks me out for two weeks. I have little energy, physically or mentally. I try to exercise, yet everything is difficult; I tire quickly.
In 2023, I discover Bryan Johnson's content. I appreciate his open-source approach, still rare in this field. Passionate about longevity since adolescence (cf. my YouTube video on biohacking), I start following his work, as well as that of other biohackers.
Early 2024: relapse. Infection with an abscess. The doctors want to operate on me, but I am reluctant. I "negotiate" an antibiotic protocol that I optimize myself, drawing on the clinical studies conducted before it was marketed.
Three doctors out of four recommend the operation. The fourth explains to me that it will not solve the root of the problem: "the inflammation persists, the treatment dosage has to be reviewed". I pass this information on, but no change is made.
Meanwhile, my blood tests are catastrophic: cholesterol, prediabetes, gamma-GT at 290… And yet I eat rather healthily, much more so than average, in any case.
I consult specialists in France, in Switzerland, in Canada, in Ireland. All of them tell me: these levels are linked to your disease or to your treatment, change nothing. If it gets worse, we will consider a specific treatment: statins, antidiabetics, etc.
Then something suddenly clicks in my head: I realize that most of the approaches aimed at slowing, or reversing, aging target inflammation. And… I have an inflammatory disease!
It is precisely at that moment that the Blueprint stack becomes available in Ireland. I dive into the subject and search for possible major incompatibilities with my treatment. Working both manually and with the help of artificial intelligence, I put my work on hold and devote myself, for the first time in my life, exclusively to my health.
I go over everything, read every study, consult doctors, and I do not identify any critical incompatibilities. I then decide to follow the stack very scrupulously, as well as part of the protocol, particularly the nutritional side. My objective is modest: 10 to 15% improvement over one year.
Result? In three weeks, I am stronger, in better shape. I can exercise again. Which had become impossible for me.
A few weeks later (I shared the progress on my Telegram channel): no more prediabetes, no more high cholesterol. All my markers are in the green. My gamma-GT is down to one-fifth of its previous level. I feel better and better.
Since then, I have continued to refine and adapt the "Life 0verride" protocol to my condition. My method is simple:
1) Reading the existing studies
2) Rigorous safety checks (especially in my context)
3) Implementing the protocol
4) Measurement (blood panel every 8 weeks)
5) If it is positive → I keep it. Negative → I eliminate it. Stable → I adjust.
My CRP decreases slowly, test after test, until it goes down below 1. Ten months later, I can say that I have never been in such good shape. Not just my blood markers: everything has changed. Cardiac checkup spotless, optimal lipid profiles, blood pressure, sleep, concentration, mood… Make of it what you will, but in the eyes of *everyone* who has been around me since: my biological age has gone backwards by several measures.
So yes, I know about survivorship bias. But…
I studied every ingredient of the stack. For each one, I found consistent studies. I then adjusted certain dosages according to my objectives.
To those who criticize: yes, not all studies are equal. Some are in vitro, others animal, others observational. Few are randomized double-blind trials. But that is how science progresses: by accumulation, by deduction, by trying things out.
No, there is no study testing precisely all these ingredients at these dosages in combination. Any more than there is a study on the simultaneous consumption of paracetamol and vanilla yogurt. And yet some people consume them…
Blueprint is not just a stack or a protocol. It is first and foremost a method. A method in which you measure for yourself what works. And if something does not suit you? You remove it. You adjust. Period.
I am not a believer, but I think I can say that the philosophy Bryan Johnson advocates is simple, and fundamentally compatible with most philosophical or spiritual visions:
Don’t die individually.
Don’t kill each other.
Don’t kill the planet.
Align AI with Don’t Die.
We are fortunate to live in a time when the impossible becomes possible, when reality surpasses the science fiction of our childhood. The real problem is not that there is a Bryan Johnson. It is that we do not have a hundred like him, to lift humanity up.
Thank you for reading, to those who had the courage.
Good evening to you all.
Take care of yourselves and your loved ones.
—
Christophe Casalegno
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